"I am Moth, a girl from the lowest part of Chrystie Street, born to a slum-house mystic and the man who broke her heart."

The Virgin Cure begins in the tenements of lower Manhattan in the year 1871. A series of betrayals lead Moth, at only twelve years old, to the wild, murky world of the Bowery, where eventually she meets Miss Everett, the owner of a brothel simply known as "The Infant School." Miss Everett caters to gentlemen who pay dearly for companions who are "willing and clean," and the most desirable of them all are young virgins like Moth.

While Moth's housemates risk falling prey to the myth of the "virgin cure"--the belief that deflowering a girl can heal the incurable and tainted--her new friend Dr. Sadie warns Moth to question and observe the world around her so she won't share the same fate. Still, Moth dreams of answering to no one but herself. There's a high price for such independence, though, and no one knows that better than a girl from Chrystie Street.